2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

Related Products

PDF 0.35 MB

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139453
    LP-184
    		99.37%
    LP-184 (compound 6), an acylfulvene analog, inhibits tumor growth. LP-184 has potent anti-cancer activity in the ovarian, colon, prostate and pancreatic cell lines. (patent WO2007019308A2).
    LP-184
  • HY-114577
    Palifosfamide tromethamine
    		Chemical 98.74%
    Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
    Palifosfamide tromethamine
  • HY-137316
    Phosphoramide mustard
    Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage.
    Phosphoramide mustard
  • HY-16293S
    Lurbinectedin-d3
    		98.25%
    Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
    Lurbinectedin-d<sub>3</sub>
  • HY-W781133
    cDPCP
    		99.9%
    cDPCP (cis-[Pt(NH3)2(N1-pyridine)Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters.
    cDPCP
  • HY-U00095
    Hepsulfam
    		Inducer 99.31%
    Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC50 of 0.91 μg/mL in a panel of different tumors.
    Hepsulfam
  • HY-119969
    Diaziquone
    		98.46%
    Diaziquone (NSC 182986), an aziridinylbenzoquinone, is a DNA alkylating agent. Diaziquone shows a broad antitumor activity against numerous transplantable murine tumors including curative activity against several intracerebrally implanted tumors. Diaziquone crosses the blood brain barrier.
    Diaziquone
  • HY-13641
    Mitobronitol
    Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia.
    Mitobronitol
  • HY-W011425
    NTPO
    NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER).
    NTPO
  • HY-130547
    BS2G Crosslinker disodium
    BS2G Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.
    BS2G Crosslinker disodium
  • HY-13585S
    Carmustine-d8
    		98.34%
    Carmustine-d8 is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
    Carmustine-d<sub>8</sub>
  • HY-W275553
    4-Decanol
    		Inhibitor 98.18%
    4-Decanol is an antimutagenic compound, that can be isolated from mustard leaves. 4-Decanol inhibits mutagenic activities of Aflatoxin B1 (HY-N6615) and MNNG (HY-128612) in Salmonella typhimurium TA100.
    4-Decanol
  • HY-13730
    Porfiromycin
    		99.52%
    Porfiromycin (N-Methylmitomycin C) is a bioreductive alkylating agent that preferentially kill hypoxic tumor cells relative to other aerobic counterparts.
    Porfiromycin
  • HY-N9460
    Sibiromycin
    Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine.
    Sibiromycin
  • HY-111965
    PF-06647263
    PF-06647263 is an ADC targeting EFNA4, consisting of EFNA4 Antibody (HY-P991109), ADC toxin Calicheamicin (HY-19609) and a linker. PF-06647263 exhibits anti-tumor activity and induces significant tumor regression in TNBC xenografts.
    PF-06647263
  • HY-W004702S
    Methyl methanesulfonate-d3
    Methyl methanesulfonate-d3 is the deuterium labeled Methyl methanesulfonate (HY-W004702). Methyl methanesulfonate is an alkylating agent which transfers methyl groups, and induces DNA damage. Methyl methanesulfonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Methyl methanesulfonate-d<sub>3</sub>
  • HY-W587524
    Carboxyphosphamide
    		Control 98.15%
    Carboxyphosphamide is an inactive metabolite of the alkylating agent Cyclophosphamide (HY-17420).
    Carboxyphosphamide
  • HY-24144
    Tesirine intermediate-2
    		99.43%
    Tesirine intermediate-2 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
    Tesirine intermediate-2
  • HY-W011123
    N-Succinimidyl 4-[4-maleimidophenyl]butyrate
    		98.0%
    N-Succinimidyl 4-[4-maleimidophenyl]butyrate is a crosslinking agent.
    N-Succinimidyl 4-[4-maleimidophenyl]butyrate
  • HY-17419R
    Ifosfamide (Standard)
    Ifosfamide (Standard) is the analytical standard of Ifosfamide. This product is intended for research and analytical applications. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
    Ifosfamide (Standard)
Cat. No. Product Name / Synonyms Application Reactivity